Nanomedicine design strategy for preferential elimination of cancer stem cells by targeted HIF-Warburg-immune evasion axis: Systematic review.
Cancer stem cells (CSCs) drive tumor recurrence, metastasis, and therapeutic resistance.Rather than exhibiting a uniform glycolytic phenotype, CSCs occupy tumor- and state-dependent metabolic configurations ranging from glycolysisdominant to oxidative phosphorylation(OXPHOS)-dependent and hybrid states. In hypoxic an...