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Author

Yu-bo Zhang

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Open access Aug 2026

SESN1 is a negative regulator of MAVS and dynamically expressed during RNA viral infection.

It is reported that SESN1 acts as a critical negative regulator of mitochondrial antiviral signaling protein (MAVS), a central hub protein in RNA-triggered innate immune response, by potentiating MAVS autophagic degradation to repress innate immune response.

Qiang-Hui Liu, Peiran Chen, Chun-Yan He et al. · 0 citations
Review Jul 2026

Targeted protein degradation: bridging chemical biology and clinical translation.

An overview of the developmental trajectory of the TPD field is provided and how diverse modalities can be leveraged to address intracellular, membrane-associated, and extracellular protein targets are discussed.

Yu-bo Zhang, Junwei Fu, Yue Liu et al. · 0 citations

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