Sensorineural hearing loss is driven by disruption of cochlear homeostasis, where dysregulated redox, ionic, and metabolic factors lead to hair cell degeneration and synaptic injury. Current strategies lack the capacity to restore the enzymatic clearance of reactive oxygen species or penetrate the blood-labyrinth barri...
Bao-Ying Xu, Xin-Rui Chen, Kai-Xuan Hu et al.· Nature Communications· 0 citations
The cGAS‐STING pathway is a pivotal therapeutic target for antitumor immunity, yet clinical translation of its small‐molecule agonists is hindered by poor tumor specificity, suboptimal pharmacokinetics, and systemic off‐target effects. Here, we report a nanocatalytic strategy based on a tumor microenvironment (TME)‐res...
ABSTRACT Inducing pyroptosis in tumor cells has emerged as a promising anticancer strategy. However, under sublethal oxidative stress, a considerable fraction of cancer cells evades pyroptosis and undergoes therapy‐induced senescence, which ultimately drives chronic inflammation and facilitates tumor relapse. Here, we...
Zi-Lu Chen, Kun Mei, Yan Yang et al.· Advancement of science· 0 citations
Whole tumor cell vaccines are uniquely positioned for personalized immunotherapy by presenting the full repertoire of tumor-associated antigens to counter tumor heterogeneity, yet their translation is persistently hindered by poor immunogenicity and the requirement for multiple administrations. Herein, we introduce a s...
Hong-Ze Ren, Qing-Ying Wu, Wei Yang et al.· Angewandte Chemie· 0 citations
A living bacterial hybrid reactor is developed by integrating Shewanella oneidensis MR-1 with Cu(II)-based zeolitic imidazolate frameworks to enable metabolism-guided and tumor-confined bioorthogonal catalysis, overcoming key limitations of conventional bioorthogonal catalysis and enabling precise, tumor-confined thera...
