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Aug 2026

Discovery of Novel Cyanoacrylates as Potential Myosin I Inhibitors with Remarkable Activity against Fusarium Species.

Fusarium head blight (FHB) is a devastating wheat disease causing yield losses and mycotoxin contamination. Phenamacril, a myosin I-targeting fungicide, has a limited antifungal spectrum. Using structure-based drug design focusing on M375 in Fusarium graminearum myosin I (FgMyoI), we synthesized 25 phenamacril derivati...

Songtao Liu, Wan-Ting Zhang, Xi-Yuan Zhu et al. · 0 citations
Open access Oct 2026

The ABCG transporter OsPDR17 mediates transport of 5,10-diketo-casbene and enhances disease resistance in rice.

Compound 5,10-diketo-casbene (DKC) is a key macrocyclic diterpenoid phytoalexin contributing to rice resistance against bacterial blight. Although its activity depends on transmembrane transport, the transporter of DKC remains unknown. Using transcriptome profiling and a yeast expression system, OsPDR17, an ABCG transp...

Ru-Yuan Wang, Xuesong Bie, Shuang Xu et al. · 0 citations

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