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Yu-Chen Liu

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Open access Sep 2026

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

ABSTRACT Renal tubular epithelial cells (RTECs) are highly metabolically active and vulnerable to pathological stress. Calcium oxalate (CaOx) crystals disrupt lipid metabolism and damage RTECs, thereby promoting nephrolithiasis. We found that SIRT5, a highly expressed desuccinylase in RTECs, was markedly reduced in kid...

Qin-Hong Jiang, Cai-Tao Dong, Yu-Chen Liu et al. · 0 citations
Open access Aug 2026

Quantitative and Targeted Regulation of Ferroptosis in Bladder Cancer: Preclinical Study

The quantitative equation derived from the data suggests that the induction of ferroptosis in bladder cancer cells can be effectively modulated by these two genes, and the experimental results indicate the system can modulate these two genes to affect the function of BCa cells without affecting the normal cells, offeri...

Ying Dong, Chao Xu, Bing Yan et al. · 0 citations

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