Open access
Oct 2026
SEC Mediates m6A Deposition and Transcription Pause Release to Drive Cell Identity Transition
ABSTRACT Background: Induced pluripotent stem cell (iPSC) reprogramming and embryonic stem cell (ESC) differentiation represent opposite models of cell identity transition, yet their regulatory mechanisms remain incompletely understood. Here, we identify the Super Elongation Complex (SEC), the most pivotal regulators o...
Zhi-Jing Zhang, Jing-Yi Xu, Yong-Hong Wu et al.
· Advancement of science · 0 citations