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Yu-Chen Yu

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Open access Oct 2026

TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology

Integrated human data provide compelling evidence that TSC1 deficiency is a hallmark of AD and is associated with mTORC1 hyperactivation, aggravated amyloid-tau pathologies, cognitive impairment, and neuroinflammation, consistent with a model in which TSC1 deficiency and mTORC1 hyperactivation may contribute to AD path...

Zheng-Zhao Liu, Yu-Chen Yu, Yu Wang et al. · 0 citations

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