Review
Open access
Sep 2026
From descriptive to generative: foundation-model approaches for spatial transcriptomics
Abstract Spatial transcriptomics has advanced the study of biological systems by facilitating the mapping of gene expression within native tissue environments. Nevertheless, the intrinsic high dimensionality, pronounced data sparsity, and intricate nonlinear relationships between tissue morphology and the transcriptome...
Ting Fan, Yu-Fei Leng, Jia-Tong Zhang et al.
· Briefings in Bioinformatics · 0 citations