Author

Yu-Fei Zhang

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Open access Sep 2026

Lenalidomide triggers ferroptosis in multiple myeloma by blocking the c-Maf/USP7 signaling pathway to induce the ubiquitination and degradation of FTH1.

Multiple myeloma (MM) is the second most common hematological malignancy. Ferroptosis, a distinct form of programmed cell death, has attracted the interest of researchers because of its unique role and biological significance across various diseases. As a first-line clinical treatment drug for MM, lenalidomide (LEN) ha...

Erhao Zhang, Ting-Ting Zhang, Jin-Jin Xu et al. · Cellular Signalling · 0 citations

Open access Jul 2026

Resveratrol-activated PI3K/AKT/mTOR signaling pathway attenuates ferroptosis by promoting NRF2/GPX4 metabolic pathway to mitigate IFN-gamma-mediated aplastic anemia

RSV is a potential therapeutic drug for ferroptosis-related AA treatment by targeting the PI3K/AKT/mTOR signaling pathway, which enhances NRF2-mediated GPX4 transcription, thereby ameliorating AA symptoms in vitro and in vivo.

Erhao Zhang, Jia-Nan Cui, Xinran Zhu et al. · Chinese Medicine · 0 citations