Author

Yu-Feng Wang

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Review Open access Sep 2026

CD97/ADGRE5 in Cancer: Structural Activation, Context-Dependent Signaling, and Therapeutic Targeting

CD97 is an adhesion G-protein-coupled receptor encoded by ADGRE5 that integrates extracellular signals (including cell adhesion, ligand binding, and mechanical stimulation) with intracellular signal transduction and is involved in tumor stemness, invasion, metastasis, and cell survival through adhesion-related signalin...

Yu-Hong Lei, Yuan Zhang, Yu-Feng Wang et al. · Cells · 0 citations