Yu-Hao Chen

Engineered bacteria reverses tumor cuproptosis resistance via cancer-associated fibroblast reprogramming for enhanced immunotherapy

Cuproptosis, a novel modality of mitochondrial copper-induced cell death, holds great therapeutic potential against cancer. However, its efficacy is limited by cancer-associated fibroblasts (CAFs), which confer the cuproptosis resistance in tumor by upregulating the copper exporter ATP7A. In this study, we developed an...