Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats
Simple Summary Postmenopausal osteoporosis is a common skeletal disorder caused mainly by increased bone loss after estrogen decline. Osteoclasts, the cells responsible for bone resorption, become overactive during estrogen deficiency and contribute to osteoporosis progression. Although estrogen is widely used to preve...