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Yu-Heng Yan

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Open access Aug 2026

ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway

Summary Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with a poor prognosis. Radiotherapy is an essential treatment strategy for SCLC but is constrained by rapid relapse and therapeutic resistance. ONC201, an orally bioavailable imipridone compound, has demonstrated clinical efficacy ag...

Yu-Heng Yan, Zhaolin Xu, Ziyang Xu et al. · 0 citations

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