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Yu-Hong Yang

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Review Open access Oct 2026

Aberrant NRF2-Dependent Cytoprotection Subverts Stress Homeostasis and Promotes Tumor Progression

Nuclear factor erythroid 2-related factor 2 (NRF2) coordinates antioxidant defense, metabolism, iron homeostasis, and proteostasis to support cellular adaptation to stress. Kelch-like ECH-associated protein 1 (KEAP1)-Cullin 3 (CUL3) continuously targets NRF2 for proteasomal degradation. Oxidative or electrophilic stres...

Gao-Qing Feng, Yu-Hong Yang, Hua-Hua Wang et al. · 0 citations

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