Yu-Hsuan Tsai

Sequence Similarity Network-Guided Discovery of a Sequence-Tolerant Cyanobactin Protease Clade for Site-Selective Peptide and Protein Modification

Proteases responsible for leader peptide removal are ubiquitous in ribosomally synthesized and post-translationally modified peptide (RiPP) biosynthetic pathways. However, many characterized RiPP proteases require specific core peptide modifications prior to cleavage, limiting their broader applicability. Here, we id...