Dual Antiplatelet Therapy in Acute Ischemic Stroke: A 2-Time-Window Study of CYP2C19 Genotypes and Functional Outcomes.
BACKGROUND Carriers of CYP2C19 loss-of-function alleles (LoFA) exhibit reduced metabolism of clopidogrel, potentially compromising the efficacy of dual antiplatelet therapy (DAPT) in acute ischemic stroke. We aimed to distinguish the impact of initial antiplatelet regimens from the discharge deescalation on functional...