Molecular Mechanisms of Natural Saponins in Treating Acute Lung Injury: Systemic Regulatory Roles Involving Multiple Cell Types and Signaling Pathways.
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening conditions characterized by severe pulmonary dysfunction, with persistently high global incidence and mortality. Although glucocorticoids, the standard pharmacotherapy for ALI/ARDS, have been reported to reduce short-term mortal...