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Yu-Jiao Liu

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Review Open access Sep 2026

Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response

Lysine lactylation (Kla) is a lactate-driven post-translational modification that covalently links lactyl groups to lysine residues, directly coupling cellular metabolic states to gene expression regulation and protein functional remodeling. Since its first report in 2019, extensive studies have confirmed that lactylat...

Yu-Fei Liu, Yu-Tong Zhou, Hui-Wen Xue et al. · 0 citations
Review Aug 2026

Targeted protein degradation: mechanistic diversity, therapeutic expansion, and clinical translation.

This review provides a roadmap for translating TPD into transformative therapies and outlines key challenges including novel E3 ligase ligand discovery, tissue selectivity, and acquired resistance, and discusses how covalent fragment screening, artificial intelligence, and expanded E3 ligase repertoires will advance ne...

Caiyu Wang, Zhibin Guo, Yu-Fei Liu et al. · 0 citations

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