3D-bioprinted dual-factor nerve conduits promote neurovascular co-regeneration via activation of the PI3K/AKT and MAPK/ERK pathways.
Peripheral nerve repair across challenging defects remains a major clinical hurdle, partly because conventional nerve guidance conduits fail to reconstruct the neurovascular microenvironment essential for coordinated regeneration. To overcome this, we engineered a 3D-bioprinted multichannel conduit composed of alginate...