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Sep 2026

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.

Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are conserved drivers of fibrosis and therapeutic targets, yet their functional heterogeneity complicates therapeutic intervention....

Clemens Hinterleitner, Valentin J. A. Barthet, Hailey V. Goldberg et al. · 0 citations
Open access Jul 2026

Epigenetic Reactivation of Lineage Differentiation to Target Leukemia

A selective small-molecule TRIM28 inhibitor is developed that binds the TRIM28 PHD-bromodomain, phenocopies TRIM28 loss across biochemical and cellular assays, exhibits low micromolar anti-leukemia activity, induces neutrophil differentiation, and synergizes with Menin inhibition.

Shandon M. Amos, Chi-Chao Chen, Yichen Xiang et al. · 0 citations

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