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Author

Yu-Ke Cen

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Aug 2026

Boosting Cytochrome P450 Electro-Catalysis: Substrate-Dependent Kinetics, Electro-Induced Activation, and NADH/NAD+ Ratio Control.

Efficient electron supply and cofactor utilization remain key bottlenecks in cytochrome P450-catalyzed oxidations. Here, we report an electro-assisted system that overcomes these limitations, using the P450 Ema1-catalyzed oxidation of avermectin B1a as a model reaction. Under a constant current of 1 mA, > 96% conversio...

Yu-Ke Cen, Yue Jiang, Jia-Jia Mou et al. · 0 citations
Sep 2026

Combinatorial Metabolic and Process Engineering for Enhanced GA4+7 Production and Tunable GA4/GA7 Ratio in Fusarium fujikuroi.

This study demonstrated that the GA4/GA7 ratio can be modulated through both molecular and fermentation strategies, and engineering a high-yielding GA4+7 producer using this Δp450-3 mutant as a platform.

Jing-Wen Jia, Zheng-Bin Zhang, Ming-Han Li et al. · 0 citations

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