Oct 2026
p62-Keap1-Nrf2 positive feedback loop protects against inorganic arsenic-induced senescence and EMT in alveolar type II cells.
Inorganic arsenic (As) exposure is known to induce pulmonary fibrosis, yet the underlying mechanisms remain incompletely understood. This study investigated the crosstalk between sequestosome 1 (SQSTM1/p62) and nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating cellular senescence and epithelial-mesenchym...
Xin-Yang Guo, Xin-Yu Ma, Li-Yi Qin et al.
· Cellular Signalling · 0 citations