Spatial Fibroblast–Macrophage Niches in Gastric Cancer: Mechanisms of Immune Exclusion, Therapeutic Resistance, and Targeted Intervention
Abstract Recent advances in immune checkpoint blockade, chemotherapy, anti-angiogenic therapy, and molecularly targeted therapies have expanded therapeutic options for gastric cancer. However, primary and acquired resistance remain major barriers to achieving durable clinical benefit. Tumor cell-intrinsic molecular fea...