Lung adenocarcinoma (LUAD) is one of the major subtypes of non-small cell lung cancer (NSCLC), but the molecular mechanisms underlying LUAD initiation and progression remain incompletely understood. In the present study, we identified TRIM46 as a key driver of LUAD progression. TRIM46 is significantly overexpressed i...
Shao-Kun Yu, Xiao Ke, Zhi-Li Liu et al.· Cell Death & Disease· 0 citations
Small cell lung cancer (SCLC) represents the most lethal subtype of lung carcinoma. Platinum-based agents, such as cisplatin and carboplatin, remain the cornerstone of first-line therapy for patients with SCLC, whether administered as chemotherapy alone or in combination with immunotherapy. However, patients frequently...
COPD and retinal vascular traits show evidence of shared genetic architecture involving vascular branching, density, and venous caliber, and support retinal vascular traits as candidate research phenotypes for investigating systemic microvascular involvement in COPD.
Yu-Li Chen, Yi-Bin Li, Yijiao Tang et al.· International Journal of COP...· 0 citations
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