Bisphosphonate-Functionalized Injectable Hydrogel Microspheres Enable Zinc-Mediated Reconstruction of a Vascularized Osteogenic Microenvironment for Osteoporotic Bone Regeneration
Osteoporotic bone regeneration remains challenging because impaired vascularization and disruption of the regenerative microenvironment compromise functional bone repair. In this study, we developed an injectable hydrogel microsphere platform with BP-mediated mineral affinity (GH-BZ) for localized and sustained Zn2+...