Transdermal patches based on pressure‐sensitive adhesives (PSAs) are widely used for the delivery of diverse drugs. However, most PSAs are difficult to adapt to the wet microenvironments of the skin (sweating, bathing, humidity), thereby exhibiting inadequate adhesiveness. Meanwhile, integrating pharmaceutical and adhe...
A pH-responsive dual-crosslinked hydrogel (OR-Mg@NK@Gel) with oxyresveratrol‑magnesium (OR-Mg) metal-phenolic cell backpacks enables enhanced penetration through the dense ECM barrier and broader intralesional distribution and holds promising translational potential.
Shuang-Qing Wang, Shi-Qi Huang, Jing-Yu Jin et al.· Journal of Controlled Releas...· 0 citations
This review systematically summarize the design principles and material engineering strategies of hydrogels, including structural construction approaches and functional regulation concepts, and places particular emphasis on recent progress in hydrogel-based therapeutic strategies across diverse human disease contexts.