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Sep 2026

FAPi-Mediated siRNA Lipid Nanoparticles for the Treatment of Liver Fibrosis.

Liver fibrosis lacks effective therapies largely due to the inability of conventional lipid nanoparticles (LNPs) to target activated hepatic stellate cells (HSCs), the primary drivers of fibrotic progression. Here, we developed a fibroblast activation protein inhibitor (FAPi)-modified LNP encapsulating heat shock prote...

Ru-Lan Feng, Shu-Lei Zhu, Zi-Jun Yao et al. · 0 citations
Open access Aug 2026

Formulation Screening and Characterization of PLGA-Based Injectable In Situ Gel Loaded with Progesterone

Objective: Conventional progesterone (P4) formulations suffer from low bioavailability, severe local irritation, and poor patient adherence due to P4’s poor aqueous solubility. This work aimed to develop and screen a biodegradable PLGA/NMP (Poly(lactic-co-glycolic acid)/N-methyl-2-pyrrolidone) injectable in situ gel fo...

Zhi-Han Zhu, Yu Liu, Ling-Lin Feng · 0 citations

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