Author

Yu-Long Deng

3 papers indexed here

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Open access Aug 2026

Multimodal Analysis Reveals Aberrant Expression of SUMO2 and Its Significant Association With Key Mechanisms of Metabolic Pathways in Hepatocellular Carcinoma.

BACKGROUND Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. However, the role of small ubiquitin-like modifier 2 (SUMO2), a core member of the small ubiquitin-like modifier (SUMO) family, regarding its expression patterns and metabolism-related functions in HCC remains inade...

Yu-Long Deng, Bei-Bei Huang, Yu-Xing Tang et al. · Frontiers in Bioscience · 0 citations

Open access Aug 2026

CRISPR Screen Reveals Pathways and Factors Driving Tyrosine Kinase Inhibitor Resistance in Hepatocellular Carcinoma

Tyrosine kinase inhibitor (TKI) resistance severely limits clinical outcomes in hepatocellular carcinoma (HCC), highlighting the urgent need to elucidate its underlying molecular mechanisms. In this study, an unbiased genome‐wide CRISPR/Cas9 screening identified novel key factors related to the therapeutic responsivene...

Siyi Chen, Li-Hua Yang, Zi-Qian Liang et al. · Cancer Medicine · 0 citations

Open access Jan 2026

A Potential miR‐1246‐5p–H3K27ac–NOL12 Regulatory Axis and Its Putative Tumour‐Promoting Function in Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide. Although the nucleolar protein NOL12 has been implicated in HCC progression, its comprehensive expression patterns, clinical significance and regulation—particularly the potential involvement of miR‐1246‐5p and H3K27ac—are not f...

Li Xiao, Yu-Long Deng, Li-Na Liang et al. · IET Systems Biology · 0 citations