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Author

Yu-Min Huang

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Open access Sep 2026

Zinc mediates the allosteric activation of Shiftless to suppress programmed -1 ribosomal frameshifting.

Many medically important viruses, including HIV-1 and severe acute respiratory syndrome coronavirus 2, utilize programmed -1 ribosomal frameshifting (-1 PRF) to synthesize certain proteins essential for the viral life cycle. Shiftless (SHFL) is an interferon-simulated, zinc finger-containing protein that restricts -1 P...

Shi-Ting He, Yong-Feng Zheng, Ru-Hong Ying et al. · 0 citations

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