Yumin Luo

Focal Cortical Dysplasia Type II: Somatic Mutations, Molecular Mechanisms, and Integrative Multi‐Omics Framework

ABSTRACT Background Focal cortical dysplasia Type II (FCD II) is a major cause of drug‐resistant epilepsy in children. Somatic mosaic variants affecting the PI3K–AKT–mTOR pathway are implicated in a substantial proportion of cases. The links between genotype, cellular pathology, epileptogenic networks, and clinical out...

Lymphatic-Immune Microenvironment Engineering via Rapamycin-Eluting Nanofibers for Meningeal Repair and Neuroprotection in Traumatic Brain Injury Rats

While current dural repair patches achieve mechanical sealing to prevent cerebrospinal fluid leakage, they fail to address the critical pathological cascades of traumatic brain injury, including structural disruption of meningeal lymphatic vessels and dysregulation of neuroimmune responses. Here, we break this therapeu...

Multilayer Validation Reveals a Glia-Associated Secretome Signature in Temporal Lobe Epilepsy