Open access
Oct 2026
Leucine-derived isovaleric acid remodels the tumor microenvironment by degrading EIF3I.
Metabolic reprogramming and immune evasion are hallmarks of cancer. Although leucine is well known for regulating protein synthesis, its role in immunometabolic interactions within the tumor microenvironment (TME) remains unclear. In this study, we found that leucine supplementation significantly inhibited tumor growth...
Jia-Hui Xu, Zi-Ming Wang, Chun-Li Wei et al.
· Pharmacological Research · 0 citations