Author

Yu-Sheng Yao

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Open access Sep 2026

The role of apolipoprotein E4 on calcium homeostasis in primary hippocampal neurons: an in vitro study

Background We previously demonstrated that apolipoprotein E (apoE4) accelerates neurodegeneration in a transgenic mouse model, but the mechanism is still unclear. A previous study reported that death-associated protein kinase 1 (DAPK1) interacts with the NR2B subunit of the N-methyl-D-aspartate (NMDA) receptor, this DA...

De-Shan Liu, Yi-Fen Zhuo, Si-Si Chen et al. · Frontiers in Neuroscience · 0 citations

Open access Aug 2026

Berberine alleviates postoperative cognitive dysfunction by suppressing microglial IDO1 induction and kynurenine pathway activation in aged mice.

Postoperative cognitive dysfunction (POCD) is a common complication of surgery in elderly patients, and no pharmacological therapy has been approved. Although indoleamine 2,3-dioxygenase 1 (IDO1)-driven kynurenine pathway activation has been linked to perioperative neurocognitive impairment, neither the cellular source...

Jia-Lin Yang, Xiaohong Liu, Tong-Tong Zhang et al. · Pharmacological Research · 0 citations