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Yu Shi

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Open access Aug 2026

Multi-omics and single-cell analysis link the pan-cancer TOP2A-immune exclusion paradox to a non-cell-autonomous dilution effect

It is clarified that TOP2A functions as a pan-cancer barometer of proliferative burden and genomic instability rather than a direct immune suppressor, and provides a framework for deploying TOP2A as a prognostic biomarker and a hypothesis-generating therapeutic target.

Jianlu Jiao, Xiu-Ping Fang, Yongjin Zhang et al. · 0 citations

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