Spatial Atlas of Upper Tract Urothelial Carcinoma Identifies SLC14A1+ and S100A8/9+ Tumor Cells as Key Determinants of Malignant Progression.
Upper tract urothelial carcinoma (UTUC) is characterized by a high incidence of muscle invasion and distinct molecular heterogeneity, with tumor microenvironment (TME) heterogeneity playing a pivotal role in its malignant progression. However, the spatial distribution patterns of functional cell populations in UTUC and...