Self-assembling pH-responsive peptide nanoparticles delivering pyrvinium pamoate induce osteosarcoma senescence through CBX4 ubiquitination-mediated inhibition of YAP1 SUMOylation.
A pH-responsive biomineralization-induced peptide self-assembly nanodelivery system (NP@PP) is developed to improve the druggability of PP and reveals a critical role of the CK1α-CBX4-YAP1 signaling axis in senescence-based osteosarcoma therapy and provides a theoretical and practical basis for the development of new n...