Author

Yu-Ting Chen

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Jul 2026

Dihydroaustrasulfone Alcohol Induces Biphasic Autophagy and Apoptosis in Leukemia Cells via PI3K/Akt and JNK Signaling Pathways

DA elicits a biphasic cellular response in U937 leukemia cells, characterized by transient cytoprotective autophagy followed by apoptotic cell death mediated through dysregulation of Bcl-2/Bax and suppression of the PI3K/Akt pathway, indicating that DA is a promising candidate for novel antileukemic therapeutic strategies.

Ruo-Han Tseng, Kuan-Ming Lai, Yu-Ting Chen et al. · Anticancer Research · 0 citations