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Author

Yu-Ting Jiang

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Clinical trial Open access Sep 2026

Ivonescimab plus chemotherapy as first-line treatment for advanced thymic carcinoma: preliminary results of a phase II trial with biomarker analyses

Abstract Thymic carcinoma is a rare, aggressive malignancy with limited treatment options. First-line platinum-based chemotherapy yields response rates below 40%, and immune checkpoint inhibitors have shown inconsistent efficacy. Ivonescimab, a programmed cell death protein 1/vascular endothelial growth factor (PD-1/VE...

Jie-Tao Ma, Li Sun, Ling-Yun Zhang et al. · 0 citations
Aug 2026

Tumor-intrinsic PHGDH inhibition sensitizes colorectal cancer to PD-1 blockade via α-ketoglutarate-mediated macrophage reprogramming.

Metabolic reprogramming of tumor cells profoundly shapes the tumor microenvironment and contributes to immunotherapy resistance in colorectal cancer (CRC). Here, we identify phosphoglycerate dehydrogenase (PHGDH), a rate-limiting enzyme in de novo serine biosynthesis, as a metabolic regulator of antitumor immunity. In...

Jie-Ping Qiu, Jingwen Wei, Jiaming Liu et al. · 0 citations

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