Multilevel synergistic anticancer mechanisms of Punica granatum L. peel polyphenols targeting the pan-cancer proliferation target PCNA: a combined analysis based on network pharmacology, molecular dynamics simulation, and UPLC-Q-TOF-HRMS
Punica granatum L. peel is rich in tannins and flavonoids. Modern pharmacological studies have indicated its multi-target anticancer potential; however, the molecular recognition mechanisms between its active components and key targets remain to be systematically clarified. In this study, network pharmacology, com...