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Author

Yu-Wei Chang

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Oct 2026

In-silico cognition signals aging and cognitive decline

Cognitive performance declines with aging, yet current assessment tools such as neuropsychological testing and task-based fMRI face limitations including variability, learning effects, and limited standardization. Here, we introduce in-silico cognition, a reservoir computing framework that models cognitive task perform...

M. Mijalkov, Jia-Wei Sun, Yu-Wei Chang et al. · 0 citations
Oct 2026

Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease

Parkinson’s disease (PD) is a heterogeneous disorder with distinct phenotypes that may emerge years before motor diagnosis. We investigated the proposed “body-first” and “brain-first” PD phenotypes across prodromal and clinical stages using longitudinal clinical, imaging, and genetic data from 2,030 participants in the...

M. Passaretti, D. Veréb, M. Mijalkov et al. · 0 citations

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