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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Yu Wu

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2 papers indexed here

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Sep 2026

Targeting ClpP Rewires the Metabolic-Immune Axis in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) critically depends on oxidative phosphorylation (OXPHOS). Mitochondrial targeted therapies are advancing into clinical trials, but metabolic vulnerabilities have been primarily explored from a tumor-intrinsic perspective. Leukemic cells can actively reshape an immunosuppressive tumor microe...

Xin-Rong Xiang, Bao-Zhu Luo, Lei Zhao et al. · 0 citations
Aug 2026

Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.

Acute myeloid leukemia/myelodysplastic syndromes (AML/MDSs) carrying p53 mutations are refractory to various standard therapies. Arsenic trioxide (ATO) may be effective in restoring function to p53 structural mutants. Here, we report that mutant p53 rescued by ATO treatment strengthened interferon responses triggered b...

Huaxin Song, Xin-Jie Chen, Shujun Xiao et al. · 1 citation

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