Sep 2026
BRD2-Mediated TGR5 Destabilization Impairs Fatty Acid Oxidation and Drives Tubular Ferroptosis in Diabetic Kidney Injury.
A BRD2-TGR5-FAO signaling axis is delineated as a central pathogenic driver of tubular lipotoxicity and ferroptosis in diabetic kidney injury, and BRD2 inhibition is position as a mechanistically grounded therapeutic strategy for diabetic kidney disease.
Hui-Mei Zang, Fu-Cheng Zang, Hai-Yan Zhang et al.
· Free Radical Biology & Medic... · 0 citations