Author

Yu-Xin Wang

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Review Open access Sep 2026

Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer

Extrachromosomal DNA (ecDNA) has emerged as a major contributor to cancer aggressiveness, yet its role extends far beyond its classical definition as a vehicle for oncogene amplification. Recent studies indicate that ecDNA functions as a dynamic regulatory platform that reshapes chromatin accessibility, enhancer activi...

Bi-Xia Liu, Lu-Yuan Zhou, Shu-Zhen Lai et al. · Molecular Cancer · 0 citations

#artificial intelligence Preprint Sep 2026

Counterfactual Self-Evolving Agents for Evidence-Grounded Reasoning

Self-play proposer--solver methods improve reasoning by generating tasks and learning from verified solutions. However, for evidence-identifiable tasks, where case-specific evidence and domain knowledge determine a checkable answer, self-play requires generating plausible cases whose answers can be independently verifi...

Xing Han, Yu-Xin Wang, Chen Chen et al. · 0 citations