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Yu-Xin Yang

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Oct 2026

Enhancing the Thermostability of Sweet Protein Thaumatin II by Integrated Rational Design

Thaumatin II is a high-intensity sweet protein whose limited thermostability restricts its industrial application. Using the previously evolved high-yield Thaumatin variant M-882 as the parental scaffold, we used an integrated rational design strategy combining HotSpot Wizard, FoldX, and PyRosetta. Candidate variants...

Le-Fei Wang, Yu-Xin Yang, Jin-Tong Dong et al. · 0 citations

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