Multiplexed Detection of Breast Cancer-Specific miRNA and Protein Biomarkers on Exosomes Using a Microfluidic Platform.
A microfluidic chip integrating two signals (ALP-driven chemiluminescence and nanobeacons-based fluorescence) into a single device was developed using breast cancer exosomes as a model, and this five-marker biomarker panel achieved a diagnostic accuracy of 99.6% in breast cancer identification.