DUSP8 Ameliorates Podocyte Mitochondrial Dysfunction via PRAS40 Dephosphorylation in Diabetic Kidney Disease.
Mitochondrial dysfunction is central to podocyte injury in diabetic kidney disease (DKD). Here, we observed consistent downregulation of dual-specificity phosphatase 8 (DUSP8) in glomeruli from patients with DKD, db/db mice, STZ/HFD-induced DKD mice, and high glucose-treated podocytes. Glomerular DUSP8 levels were posi...