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Review Open access Oct 2026

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

ABSTRACT Patients with type 2 diabetes mellitus (T2DM) often present with normal or even elevated bone mineral density (BMD), yet exhibit a significantly increased fracture risk—a phenomenon referred to as the ‘diabetic bone paradox’. This discrepancy underscores the inadequacy of conventional BMD‐centred assessment sy...

Chao-Li Wu, Jun Zou, Yu Yuan · 0 citations
Review Open access Oct 2026

The Role of Glucose Metabolic Reprogramming in Exercise-Attenuated Osteoporosis: a Narrative Review

The aging population has led to a significant increase in the prevalence of osteoporosis, making it an important public health issue. Emerging evidence suggests that osteoporosis is related to glucose metabolic reprogramming (GMR). Exercise is an effective non-pharmacological intervention method, and regulating GMR may...

Chu Li, Yu-Ting He, Kai-Hong Weng et al. · 0 citations

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