Author

Yu-Yun Zhou

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Open access Sep 2026

Securidaca inappendiculata Extract Mitigates Joint Damage in Collagen‐Induced Arthritis Rats Through Modulation of the SIRT1/HIF‐1α/Glycolysis Pathway

Mechanistic studies revealed that XAN attenuates inflammation by regulating the SIRT1/HIF‐1α/glycolysis signaling axis in macrophages, indicating that its anti‐inflammatory activity involves modulation of cellular energy metabolism.

Yu-Yan Zhou, Yu-Yun Zhou, Ruo-Xuan Xiang et al. · Pharmacology Research & Pers... · 0 citations

Aug 2026

Network Pharmacology and Experimental Validation of a Securidaca inappendiculata Xanthone Fraction Targeting Rheumatoid Arthritis via the PI3K/AKT/mTOR/HIF-1α/GSK-3β Axis.

This work elucidated the anti-RA mechanism of S. inappendiculata: eight xanthones acted on the PI3K/AKT/mTOR/HIF-1α/GSK-3β axis to induce M1 macrophage apoptosis, validating the integrated approach and laying groundwork for RA treatment and natural product research.

Xuan Chen, Bing-Ru Fan, Ting Wang et al. · Current Computer - Aided Dru... · 0 citations