Review
Open access
Oct 2026
Bidirectional Crosstalk Between cGAS-STING and Necroptosis: From Mitochondrial DNA Release to Inflammatory Disease
: The cGAS-STING pathway, a cornerstone of cytosolic DNA sensing, and necroptosis, a pro-inflammatory regulated cell death modality, are increasingly recognized as intimately interconnected axes that profoundly influence disease pathogenesis. This review synthesizes current knowledge on their bidirectional crosstalk, e...
Hong-Quan Wang, Zhi-Ji Wang, Hui Zhang et al.
· Drug Design, Development and... · 0 citations