Sep 2026
Diosgenin suppresses ALOX5 expression through Histone acetyltransferase KAT2A-mediated H3K27ac modification to attenuate macrophage ferroptosis and foam cell formation in atherosclerosis.
Diosgenin attenuated macrophage ferroptosis and foam cell formation in AS at least in part by suppressing ALOX5 expression through KAT2A-mediated H3K27ac modification, which provides new therapeutic targets for AS treatment.
Qun Huang, Hui-Ping Ou, Yuan-Bin Li et al.
· International Journal of Bio... · 0 citations