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Author

Yuan Chen

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2 papers indexed here

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Review Sep 2026

The cGAS-STING signaling in hepatocellular carcinoma: A spatiotemporally gated immune switch linking pro-tumorigenic immune evasion and anti-tumor therapeutic response.

Hepatocellular carcinoma (HCC) arises from chronic inflammation and immune tolerance, posing substantial challenges for immunotherapy. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling is a central immunological hub linking innate immune sensing to adaptive immune responses in tumors. In...

Yuan Chen, Yu-Hong An, Chao-Qun Wang et al. · 0 citations
Open access Aug 2026

NBR1-Mediated Autophagic Degradation of YTHDF1 Curtails FDX1 Translation to Drive Concurrent Multikinase Inhibitor Resistance and Cuproptosis Tolerance

Background: Cancer cells frequently acquire adaptive resistance to targeted therapies; however, strategies capable of concurrently overcoming treatment tolerance and reactivating cell death pathways are currently lacking. Here, we investigated the dual role of ferredoxin 1 (FDX1) in modulating both multikinase inhibito...

Wei-Kai Wang, Xin Jiang, Xiaona Chen et al. · 0 citations

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